Organ |
liver |
Age classes |
adult |
Gender |
F+M |
Condition |
12 months |
phase I metabolism > CYP3A4/5 > midazolam 1'-hydroxylation > microsomes |
5400 pmol/min/mg protein
|
Murayama et al. 2009 - Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., and Yamazaki, H. (2009) Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metabolism & Pharmacokinetics, 24(4): 404-8.
|
phase I metabolism > CYP3A > midazolam α-hydroxylation > microsomes |
4600 pmol/min/mg protein
|
Murayama et al. 2009 - Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., and Yamazaki, H. (2009) Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metabolism & Pharmacokinetics, 24(4): 404-8.
|
phase I metabolism > CYP2A6 > coumarin 7-hydroxylation > microsomes |
32 pmol/min/mg protein
|
Murayama et al. 2009 - Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., and Yamazaki, H. (2009) Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metabolism & Pharmacokinetics, 24(4): 404-8.
|
phase I metabolism > CYP2A > testosterone 7α-hydroxylation > microsomes |
< 0.01 pmol/min/mg protein
|
Murayama et al. 2009 - Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., and Yamazaki, H. (2009) Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metabolism & Pharmacokinetics, 24(4): 404-8.
|
phase I metabolism > CYP1A > 7-ethoxycoumarin O-deethylation > microsomes |
320 pmol/min/mg protein
|
Murayama et al. 2009 - Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., and Yamazaki, H. (2009) Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metabolism & Pharmacokinetics, 24(4): 404-8.
|